Portal:Local anesthetics

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Introduction

Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom)

A local anesthetic (LA) is a medication that causes reversible absence of pain sensation. When it is used on specific nerve pathways (local anesthetic nerve block), paralysis (loss of muscle power) also can be achieved.

Clinical LAs belong to one of two classes: aminoamide and aminoester local anesthetics. Synthetic LAs are structurally related to cocaine. They differ from cocaine mainly in that they have a very low abuse potential and do not produce hypertension or (with few exceptions) vasoconstriction.

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