October 3 – Long Island University announced that it would merge its two current athletic programs—the LIU Brooklyn Blackbirds, full members of the NEC, and the Division II LIU Post Pioneers—effective with the 2019–20 school year. The new program will compete under the LIU name with a new nickname and retain LIU Brooklyn's Division I and NEC memberships. This change will have minimal effect on the existing LIU Brooklyn women's basketball program, as LIU has announced that the unified basketball team will be based at the Brooklyn campus.
November 18 – Sabrina Ionescu recorded her 12th career triple-double in Oregon's 102–82 win over Buffalo. Already the holder of the all-divisions NCAA women's record for career triple-doubles, Ionescu equaled the NCAA record for all players regardless of sex, previously held by former BYU men's player Kyle Collinsworth.
Six schools joined new conferences for the 2018–19 season. Four schools switched between Division I conferences for the 2018–19 season. In addition, two schools moved from Division II starting this season. The former Division II schools are ineligible for NCAA-sponsored postseason play until completing their D-I transitions in 2022.
Houston initially planned to reopen the renamed Fertitta Center (originally Hofheinz Pavilion) by the start of the 2018–19 season, but construction delays have pushed the expected reopening date to December 2018.
Robert Morris planned to open the new UPMC Events Center on the site of its former on-campus Sewall Center in January 2019, but the opening has now been delayed to that summer. Until the new arena opens, the Colonials will continue to use the Student Recreation and Fitness Center, a building in the school's North Athletic Complex that opened in September 2017 as part of the UPMC Events Center project.
An upset is a victory by an underdog team. In the context of NCAA Division I Women's Basketball, this generally constitutes an unranked team defeating a team currently ranked in the Top 25. This list will highlight those upsets of ranked teams by unranked teams as well as upsets of #1 teams. Rankings are from the AP poll.
Bold type indicates winning teams in "true road games"—i.e., those played on an opponent's home court (including secondary homes, such as Intrust Bank Arena for Wichita State).